Three of the five macroalgal extracts caused a significant increase of H3K9 deacetylation, and the effect was most pronounced for F. dichitus. So can we activate SIRT6 in humans and have the same effect? and Maija Lahtela-Kakkonen and Luigi Ferrucci and Maria Hayes and Ruin Moaddel". Critics have pointed out that theres no direct proof that activating the sirtuin 6 gene will make us live years or decades longer. If you choose to comment and participate in the sub, scientific rigor is expected! However activating SIRT6 extended lifespan by 27%, https://www.nature.com/articles/s41467-021-23545-7. Sirtuin 1 improves health-span; Sirtuin 6 extends lifespan in laboratory studies. All rights reserved. Just more arrows in the quiver. The owner of this blog makes no representations as to the accuracy or completeness of any information on this site or found by following any link on this site. Of those linoleic acid performed the best with oleic a close second (see figure 2), so flax seed oil and olive oil may help here, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829447/, quercetin is a SIRT6 modulator, meaning it has both activating and inhibiting effects on SIRT6, https://www.nature.com/articles/s41598-019-55654-1. Liver-specific deletion of SIRT6 results in increased glycolysis, triglyceride synthesis, reduced -oxidation, and fatty liver formation. Your changes will in fact be stored however can be lost at all times. Otherwise they are toxic -- the seeds which are inside the berries contain chemicals that metabolize into cyanide. Also elderberries have lots of medicinal properties such as being anti flu, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056848/, I don't consider anything a "magic bullet". In terms of the specifics of sirtuin 6 activators, elderberries (fresh from the plant) contain small amounts of cyanide. S more. Authors: SIRT6 Overexpression Extends Lifespan in Mice: Fucoidan as bio-functional molecule: Insights into the anti-inflammatory potential and associated molecular mechanisms, To Save 10% on Supplements from DoNotAge: Use the Discount CodePATHWAYS. Guangcai Gong Ive been taking two sirtuin 6 activators, Gaia Herbs Black Elderberry Extract and DoNotAges SIRT6 Activator, for about six months. The author states: However, commercial preparations and cooked berries do not contain cyanide, so there are no reports of fatalities from eating these. Iodine is beneficial in proper amounts, but its true that too much can be problematic. http://phenol-explorer.eu/contents/polyphenol/9, The seaweed extract fucoidan also activates SIRT6, https://pubmed.ncbi.nlm.nih.gov/28635654/. https://www.ncbi.nlm.nih.gov/pubmed/6632988/, Luigi Fontana Samuel Klein John O. Holloszy Bhartur N. Premachandra Effect of Long-Term Calorie Restriction with Adequate Protein and Micronutrients on Thyroid Hormones https://academic.oup.com/jcem/article/91/8/3232/2656790, Andreea Soare, Roberto Cangemi, Daniela Omodei, John O. Holloszy, and Luigi Fontana Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117452/, Jill Waalen Joel N. Buxbaum Is Older Colder or Colder Older? Find out more about the company LUMITOS and our team. Here, we show that overexpression ofSIRT6, but not SIRT1, extends lifespan in C57BL/6JOlaHsd mice in both sexes. 11, Pages 1719: Building Retrofit with Photovoltaics: Construction and Performance of a BIPV Ventilated Faade These compounds have several biological activities, including anti-inflammatory, hepatoprotective, anti-tumor, anti-hypertensive, and anti-diabetic activity, although in most cases their mechanisms of action are not understood. One is to do a water fast for ten days or more. Various supplements use a mixture of macroalgae, vitamins or other ingredients. Mendeley users who have this article in their library. By continuing you agree to the use of cookies. so even if this SIRT6 thing doesn't pan out, the substances that theoretically boost it also have many other health benefits and therefore adding those substances to your diet is likely to only have beneficial effects. UR - http://www.scopus.com/inward/record.url?scp=85023180740&partnerID=8YFLogxK, UR - http://www.scopus.com/inward/citedby.url?scp=85023180740&partnerID=8YFLogxK, Powered by Pure, Scopus & Elsevier Fingerprint Engine 2022 Elsevier B.V, We use cookies to help provide and enhance our service and tailor content. /. Affiliate links help to keep the website free to use. Cancel Affiliate disclosure: Any links above marked with an asterisk (*) means it is an affiliated link which sometimes results in a payment or benefit to the club. Based on these insights, we identified isoquercetin as a ligand that can discriminate both sites and thus activates Sirt6 with increased specificity. The compound responsible for this in vitro activity was identified by mass spectrometry as fucoidan.". Your browser does not support JavaScript. Nils Osmar is an artist, writer, filmmaker, and teacher. Nuria Martn-Chivelet My reasoning is that the sirtuin genes are NAD dependent; theyre most effective if NAD levels are high in the body. author = "Rahnasto-Rilla, {Minna K.} and Padraig McLoughlin and Tomasz Kulikowicz and Maire Doyle and Bohr, {Vilhelm A.} The longest-lived populations of people did not overconsume elderberries, yet nobody has beat them yet. Your email address will not be published. Building more, Energies, Vol. I discuss some of these changes in this video: A more recent change is that I have fewer aches and pains after hitting the gym. I take lots of supplements, so I dont know for sure whether these supplements alone were solely responsible for these changes, or whether it was the fact that I was taking it while also taking NMN, resveratrol, Ca-AKG, ashwagandha, and several other supplements, and eating foods high in compounds such as CoQ10 and spermidine, which made it so effective for me. Taking NMN with Lecithin for a Mental Boost, When to take NAD Boosters? @article{c9ed7644ed9a402892c342e6b3ff2782. The compound responsible for this in vitro activity was identified by mass spectrometry as fucoidan. "We have identified those that are really strong inducers of sirtuin 6 activity, - Gorbunova. You are currently not logged in to my.bionity.com . and Blackberries and Raspberries---Think l'll start eating them tomorrow, freeze dried elderberry powder makes a great addition to my morning smoothie. Concerns are sometimes raised that sirtuin activators, like other supplements, might throw the body out of balance. Energies doi: 10.3390/en11071708 Ping Wang But do like taking supplement holidays now and then, in the form of taking a weekend off from all supplements; then I resume taking them on Monday. Brown seaweeds contain many bioactive compounds, including polyphenols, polysaccharides, fucosterol, and fucoxantin. As I mentioned, I felt an improvement in my physical and mental energy after starting the above supplements (along with an array of other supplements Id already been taking). SIRT6 represses glycolysis in an HIF1-dependent manner32, thereby acting as a tumor suppressor by inhibiting the Warburg effect33. Energies, Vol. Unfortunately I dont have a discount code for Gaia at this time. by Nils Osmar. But I had been taking those other supplements and eating those foods, for months; adding the sirtuin 6 activators was almost certainly a factor. To use all functions of this page, please activate cookies in your browser. So the longevity community has been all abuzz this week about this study showing a 27% increase in lifespan in mice by activating SIRT6, first off there are 7 sirtuins in the human body, this is what sirtuins are, Sirtuins are a class of proteins that are implicated in influencing cellular processes like aging, transcription, apoptosis, inflammation[6] and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Fucoidan for instance has very strong anti cancer properties, https://cancerci.biomedcentral.com/articles/10.1186/s12935-020-01233-8. Always eat your dark berries with some fat to maximize bioavailability of cyanidins, the freeze drying process preserves the flavonoids. [7], This study showed that activating SIRT1 (resveratrol) did nothing to effect life span. Authors: The identification of a SIRT6 activator from brown algae fucus distichus. ..people in Japan and South Korea have the highest life expectancy and they eat a lot of seaweed," - Vera Gorbunova, Scientific advisor at Do Not Age. According to this Healthline article, the answer is no. The Association of Age With Body Temperature in 18,630 Individuals https://academic.oup.com/biomedgerontology/article/66A/5/487/571283, A cross-section analysis of FT3 age-related changes in a group of old and oldest-old subjects, including centenarians relatives, shows that a down-regulated thyroid function has a familial component and is related to longevity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956534/, M. P. Rozing J. J. Houwing-Duistermaat P. E. Slagboom M. Beekman M. Frolich A. J. M. de Craen R. G. J. Westendorp D. van Heemst Familial Longevity Is Associated with Decreased Thyroid Function https://academic.oup.com/jcem/article/95/11/4979/2835245, Can Enhanced Autophagy Be Associated with Human Longevity? The compound responsible for this in vitro activity was identified by mass spectrometry as fucoidan. How likely do you think these kinds of things are to work, unless one already has the CRON phenotype and is just putting icing on the cake? Importantly, this sub is not for people to request or provide ANY dietary, nutritional or medical advice. We find that quercetin activates Sirt6 via the isoform-specific binding site for pyrrolo[1,2-a]quinoxalines. I dont mean this as a put-down of Doctors Best; I take some of their other products and like them; but I stopped taking their fucoidan after two bottles. This subreddit has been created to serve as a neutral ground for exchanging and discussing scientific evidence relating to human nutrition. Our results thus provide a structural basis for Sirtuin effects of quercetin-related compounds and helpful insights for Sirt6-targeted drug development. I do notice when I take it by itself that its mentally stimulating, kind of like having drunk or four cups of coffee. 1997-2022 LUMITOS AG, All rights reserved, https://www.bionity.com/en/publications/1095663/, More about Molecular Diversity Preservation International, Your browser is not current. DoNotAge has chosen to market fucoidan from Fucus Vesiculosus. myristic, oleic, and linoleic acids induce up to a 35-fold increase in catalytic efficiency of SIRT6. Some people have raised concerns that taking them could increase iodine levels in the body, and could in theory result in thyroid problems. Energies doi: 10.3390/en11071719 These results emphasize the potential of targeting SIRT6 for maintaining energy metabolism and reducing age-related frailty. As with anything, we need to aim to maintain a proper balance. I then added DoNotAges SIRT6 Activator, taking it along with the elderberry product and also adding 1 gram of NMN and 0.5 grams of NR (both also from DoNotAge). Minna K. Rahnasto-Rilla, Padraig McLoughlin, Tomasz Kulikowicz, Maire Doyle, Vilhelm A. Bohr, Maija Lahtela-Kakkonen, Luigi Ferrucci, Maria Hayes, Ruin Moaddel, Research output: Contribution to journal Article peer-review. It went beyond the slight energy boost that Id felt from taking the elderberry alone. The compound responsible for this in vitro activity was identified by mass spectrometry as fucoidan. For a 10% savings on all of DoNotAges products, use the code PATHWAYS when making a purchase. Faustino Chenlo Just a quick FYI: Elderberries are toxic if they're not cooked before you ingest them. I had been taking DoNotAges SIRT 6 Activator along with Gaias Black Elderberry Extract for about two months when I noticed some changes in my body. https://www.liebertpub.com/doi/10.1089/rej.2014.1607, Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. My notice: In this case it looks like it worked--at least to some extent, but what's the nature of the transgenic mice used? These compounds have several biological activities, including anti-inflammatory, hepatoprotective, anti-tumor, anti-hypertensive, and anti-diabetic activity, although in most cases their mechanisms of action are not understood. 2017 by the authors. Welcome to r/ScientificNutrition! (Juara) Intact Fruit Using NearInfrared (NIR) Spectroscopy and Linear Discriminant Analysis, Particle Size Distribution of Brown and White Rice during Gastric Digestion Measured by Image Analysis, A phase I study to assess the single and multiple dose pharmacokinetics of THC/CBD oromucosal spray, Rahnasto-Rilla, Minna K.; McLoughlin, Padraig ; Kulikowicz, Tomasz ; Doyle, Maire ; Bohr, Vilhelm A.; Lahtela-Kakkonen, Maija ; Ferrucci, Luigi ; Hayes, Maria ; Moaddel, Ruin. Save my name, email, and website in this browser for the next time I comment. In this study, extracts generated from five brown algae (Fucus dichitus, Fucus vesiculosus (Linnaeus), Cytoseira tamariscofolia, Cytoseira nodacaulis, Alaria esculenta) were tested for their ability to activate SIRT6 resulting in H3K9 deacetylation. (For a full list of my current supplements and when I take them, see this article.). Three of the five macroalgal extracts caused a significant increase of H3K9 deacetylation, and the effect was most pronounced for F. dichitus. The reason we test on animals is that they have relatively short lifespans; it would take longer than a typical human lifespan to prove beyond doubt that a supplement or other protocol extends the lifespan in human beings. You can activate the sirtuin 6 gene in a number of ways. Co-director Rochester Aging Research Center. This study, published in Nature Communcations, is a good summary: Restoration of energy homeostasis by SIRT6 extends healthy lifespan, For more information about the study, see: SIRT6 Overexpression Extends Lifespan in Mice: A significant amount of data demonstrate the major role of SIRT6 in metabolism31. If you would like to try DoNotAges SIRT6 Activator, Ive put information about a discount code below; it makes it a bit more affordable. SIRT6Activator is a natural product derived from a strain of seaweed is called Fucus Vesiculosus. Marine Drugs, 15(6). liveforever.club is a participant in the Amazon Services LLC Associates Program. Copyright Live Forever Club CIC. Kuskana Kubaha Welcome to r/ScientificNutrition. Read More Taking NMN with Lecithin for a Mental BoostContinue, Read More When to take NAD Boosters? Energies, Vol. NMN and NR are both effective NAD activators. DISCLAIMER: All content provided on this website is for informational purposes only. When I originally became interested in SIRT6 activation, I started taking Doctors Best fucoidan supplement. Three of the five macroalgal extracts caused a significant increase of H3K9 deacetylation, and the effect was most pronounced for F. dichitus. On a mission is to extend healthy lifespan for as many people as possible. https://doi.org/10.3390/md15060190, Biochemistry, Genetics and Molecular Bi 10, Pharmacology, Toxicology and Pharmaceut 6, Save time finding and organizing research with Mendeley. Thus, given SIRT6s major role in aging, the broader metabolic role of SIRT6 under fasting as well as the effect of SIRT6 overexpression on metabolism in the context of aging should be described. https://www.ncbi.nlm.nih.gov/pubmed/15571545, Iris Postmus Joris Deelen Sanaz Sedaghat Stella Trompet Anton JM de Craen Bastiaan T Heijmans Oscar H Franco Albert Hofman Abbas Dehghan P Eline Slagboom Rudi GJ Westendorp LDL cholesterol still a problem in old age? In this study, extracts generated from five brown algae (Fucus dichitus, Fucus vesiculosus (Linnaeus), Cytoseira tamariscofolia, Cytoseira nodacaulis, Alaria esculenta) were tested for their ability to activate SIRT6 resulting in H3K9 deacetylation. I dont know whether this is cause and effect, but its consistent with the known anti-inflammatory effects of fucoidan. Medical disclaimer. Press question mark to learn the rest of the keyboard shortcuts, Mediterranean diet w/ lot of leafy greens, Vegopaleoterranian | eTRFMD | Still No Salt, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC404101/, https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2012.00825.x, https://www.ncbi.nlm.nih.gov/pubmed/16412867, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812805/, http://sabatinilab.wi.mit.edu/pubs/2013/Lamming2.pdf, https://www.ncbi.nlm.nih.gov/pubmed/15571545, https://academic.oup.com/ije/article/44/2/604/753171#91897274, https://www.ncbi.nlm.nih.gov/pubmed/6632988/, https://academic.oup.com/jcem/article/91/8/3232/2656790, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117452/, https://academic.oup.com/biomedgerontology/article/66A/5/487/571283, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956534/, https://academic.oup.com/jcem/article/95/11/4979/2835245, https://www.liebertpub.com/doi/10.1089/rej.2014.1607, https://www.ncbi.nlm.nih.gov/m/pubmed/30352807/. 11, Pages 1708: A Simplified Calculation Method for Building Envelope Cooling Loads in Central South China We do need some iodine but if we get an excess amount, which could occur if we have several sources of iodine in our diets, it can cause health problems. Furthermore, we find that quercetin derivatives that inhibit rather than activate Sirt6 exploit the same general Sirt6 binding site as the activators, identifying it as a versatile allosteric site for Sirt6 modulation. More publications by Molecular Diversity Preservation International, Use of textile dyeing technology to create an infectionresistant functionalized polyester biomaterial, Polycaprolactone fiber meshes provide a 3D environment suitable for cultivation and differentiation of melanocytes from the outer root sheath of hair follicle, A New Validated HPLC Method for the Determination of Quercetin: Application to Study Pharmacokinetics in Rats, Migration of phthalates from soft PVC packaging into shower and bath gels and assessment of consumer risk, The Bryce Jordan Center Seating Chart Wrestling,
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